NCAA Football Week 15 Betting Lines And Odds Comparisons At US Sportsbooks

Week 15 of the NCAA football season is already here, and most teams are starting to wrap up regular-season action. There are still some conference races to be decided, and the top teams in the country are still trying to position themselves for a spot in the College Football Playoff. 

There will likely be some games canceled or postponed throughout the week as that has been the norm, but as of now, there is a full slate of games on tap. Here are 12 of the biggest NCAA Football games set to take place in Week 15 with a quick betting overview of each game. 

Saturday, Dec. 12

Illinois Fighting Illini at Northwestern Wildcats (-13.5)

The 5-1 Northwestern Wildcats will host the 2-4 Illinois Fighting Illini on Saturday in a great Big Ten rivalry game. You can usually throw the records out the window when these teams meet up as there have been some strange results in this rivalry. 

Illinois is running for more than 210 yards per game this season, and that rushing attack will need to be great in this game. The Fighting Illini have some holes on defense, and they gave up 35 points in a Week 14 loss to Iowa. 

Northwestern is allowing less than 16 points per game, but that defense allowed 29 points in an upset loss to Michigan State last time out. The Wildcats have already clinched a spot in the Big Ten Championship Game, but they can't afford any more losses. 

Northwestern will win this game at home, but don't expect a blowout. Take the 13.5 points and bet on the Fighting Illini to give their rival a battle on Saturday.

Purdue Boilermakers at Indiana Hoosiers (-10.5)

Indiana state rivals will meet up as the 6-1 Indiana Hoosiers host the 2-4 Purdue Boilermakers. Indiana continues to climb up the rankings while Purdue is looking to play the role of spoiler in this one.

Purdue just suffered a 37-27 loss to Nebraska on Saturday, and the Boilermakers have now lost four straight. Purdue is averaging more than 309 passing yards per game, but this offense needs to find balance against a good Indiana defense.

Indiana is without star quarterback Michael Penix Jr. for the rest of the season, but it did not stop the Hoosiers in a 14-6 win over Wisconsin on Saturday. The Hoosiers are outscoring opponents by more than 10 points per game, and there aren't many holes on this roster.

The loss of Penix hurts the Hoosiers, but that defense will get the job done in this one. Take the Indiana Hoosiers -10.5 over the Purdue Boilermakers. 

Wisconsin Badgers at Iowa Hawkeyes (-2.5)

The 2-2 Wisconsin Badgers will be in Iowa City on Saturday for a matchup with the 5-2 Hawkeyes. These two teams were expected to compete for the Big Ten West title, but Northwestern has already clinched at least a tie for the top spot and the division's spot in the Big Ten Championship Game.

Wisconsin has been a mess on offense, scoring just 13 total points in its last two games. The Badgers are running the football well, but freshman quarterback Graham Mertz has to find his rhythm.

Iowa has now won five straight games, and both sides of the ball are playing well. The Hawkeyes are outscoring opponents by 15 points per game, and Iowa is averaging almost 180 rushing yards. 

The Badgers are in a bit of a freefall, and things won't get better in this one. Take the Iowa Hawkeyes -2.5 over their Big Ten West rival. 

Washington Huskies at Oregon Ducks (-4.5)

Pac-12 North rivals will meet up on Saturday in a game that will likely determine the division winner. Washington enters the game with a 3-1 record, while the Oregon Ducks have slipped to 3-2. 

Washington is scoring almost 31 points per game, but the defense has taken a step back this season. The Huskies gave up 31 points in a loss to Stanford, and big plays have hurt this team.

Oregon was stunned by rival Oregon State last week, and the Ducks will need to regroup in a hurry. Quarterback Tyler Slough has thrown 11 touchdowns passed through five games, and the Ducks have the potential to score in a hurry.

Both teams are struggling a bit of late, but Oregon will figure things out. Take the Ducks -4.5 over the Washington Huskies in a high-scoring affair. 

Michigan Wolverines at Ohio State Buckeyes (-29.5)

Perhaps the biggest rivalry in college football will take place on Saturday, but this game has a historically large spread. Ohio State is a perfect 5-0 this season, while the Michigan Wolverines are just 2-4.

Michigan has allowed more than 34 points per game, and that defense could be a huge problem in this game against the Buckeyes. The Wolverines will also need to run the ball effectively to give their defense a chance. 

Ohio State is one of the most explosive offensive teams in the country, and it can score in a variety of ways. Quarterback Justin Fields has thrown for 1,407 yards and 15 touchdowns, and he is one of the most electric players in the country.

The Buckeyes are going to win this game big, but it's hard to see them covering 29.5 points. Look for Michigan to keep the final score respectable, and taking the points is the best bet. 

Georgia Bulldogs (-12.5) at Missouri Tigers

The 5-3 Missouri Tigers will host the 6-2 Georgia Bulldogs in an SEC East showdown on Saturday. While both teams have had solid seasons, neither team has a shot of reaching the SEC Championship Game. 

Georgia is running for more than 172 yards per game, and the offense has finally started to figure some things out. The defense has not been as dominant as expected, but that unit is still allowing just 20 points per contest.

Missouri is coming into this game with a ton of momentum after earning a 50-48 win over Arkansas on Saturday. The Tigers want to play fast, but that strategy might not work against a stout Georgia team. 

Look for the Bulldogs to take control of this one, and taking Georgia -12.5 is the right play. 

Oklahoma Sooners (-10.5) at West Virginia Mountaineers

The 7-2 Oklahoma Sooners are still alive in the Big 12 race, but they face a tough matchup against the 5-4 West Virginia Mountaineers. Oklahoma wants to win this game on offense, while West Virginia will try to win it on defense. 

Oklahoma quarterback Spencer Rattler has thrown for over 2,500 yards and 24 touchdowns this season, and the Sooners will throw the ball a ton. Oklahoma will give up some points, but they believe that their offense will get it right back.

West Virginia is allowing just 20 points per game, and the Mountaineers can't afford to get into a shootout. The Mountaineers are traditionally strong at home, but the lack of a full crowd changes things.

Oklahoma has figured things out, and it will stay red-hot with a blowout win over West Virginia in this game. 

North Carolina Tar Heels at Miami Hurricanes (-3.5)

One of the best games in Week 15 will take place in the ACC between a pair of ranked teams. The 8-1 Miami Hurricanes will host the 7-3 North Carolina Tar Heels as both teams look to improve their bowl standing. 

North Carolina quarterback Sam Howell has thrown for over 3,100 yards, and the Tar Heels will take some deep shots. This team does have work to do on defense as they are allowing nearly 30 points per game. 

Miami is giving up just 22 points per game, and it just kept Duke from scoring a point in its most recent outing. The Hurricanes can score as well, but their defense could be the difference in this game. 

Look for the Hurricanes to take control at home and cover the small 3.5-point spread in this game. 

Cincinnati Bearcats (-12.5) at Tulsa Golden Hurricane

First place in the American Athletic Conference will be on the line when Tulsa hosts Cincinnati. The Bearcats are a perfect 9-0 on the season, while the Tulsa Golden Hurricane have lost a non-conference game to Oklahoma State. 

Cincinnati is scoring 41 points per game, and quarterback Desmond Ridder is one of the most underrated players in the country. The Bearcats are winning games by more than 25 points per contest, and they have rarely been tested.

Tulsa is holding opponents to just 20 points per game, and that defense will need to be great in this game. The Golden Hurricane can run the football, and stringing long drives together could keep this one close.

Cincinnati just has a much deeper roster, and it's hard to see it struggling in this game. Take the Bearcats -12.5 over the Tulsa Golden Hurricane on Saturday. 

LSU Tigers at Florida Gators (-24.5)

The LSU Tigers are a big underdog again this weekend, this time in Florida. LSU enters play with a record of just 3-5 while the Gators are 8-1 and winners of the SEC East.

LSU gave up 55 points in a blowout loss to Alabama on Saturday, and this defense has been a mess all season. The Tigers are averaging more than 300 passing yards per game, but that has not been good enough. 

Florida quarterback Kyle Trask is a Heisman Trophy frontrunner after throwing for more than 3,200 yards and 38 touchdowns. The Gators will give up some points, but that offense is almost impossible to stop. 

The defending national champions have really struggled in 2020, and things won't improve in this one. Take the Florida Gators -24.5 over the LSU Tigers on Saturday. 

USC Trojans (-3.5) at UCLA Bruins

The USC Trojans and UCLA Bruins are bitter rivals, and this could shape up to be a great battle on Saturday night. UCLA enters play with a record of just 3-2, while the Trojans are a perfect 4-0. 

USC quarterback Kedon Slovis has thrown for more than 300 yards per game, and the Trojans want to play fast. The Trojans have been getting off to slow starts, and that problem will need to be corrected on Saturday.

UCLA will look to run the ball on Saturday, as it is averaging more than 227 rushing yards per game. The Bruins can't afford to get into a shootout with their rivals, but they have a defense to keep this one close.

This will be a huge test for USC, but they will find a way to pull through late. Take the USC Trojans -3.5 over the UCLA Bruins in this huge rivalry game.

Ole Miss Rebels at Texas A&M Aggies (-14.5)

The 7-1 Texas A&M Aggies host the 4-4 Ole Miss Rebels in what could be the highest-scoring game of the weekend. Texas A&M won't reach the SEC Championship Game, but it is still in the hunt for a College Football Playoff berth. 

Ole Miss enters play averaging nearly 40 points per game, and it wants to throw the football. That strategy has worked for the Rebels at times this season, but it has put a ton of pressure on the defense.

Texas A&M quarterback Kellen Mond has thrown 18 touchdown passes, and he continues to improve his draft stock. The Aggies are giving up just 22 points per game, and that defense will play a role in this matchup.

Expect a ton of points scored in this game, but at some point, the A&M defense will take over. Bet the Texas A&M Aggies -14.5 over the Ole Miss Rebels in a game that they must win.